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Metaxalone is well absorbed orally with an absolute bioavailability of 75%. Metaxalone has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
Metaxalone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Other medicines´┐ŻAlthough certain medicines should not be used together at all,
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Forty patients were treated with either Metaxalone suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Metaxalone has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
The analgesic activity of Metaxalone is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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The product information for Metaxalone states that convulsions have been reported in patients using Metaxalone at the recommended dose levels and that the risk
Metaxalone is found in breast milk. Do not breast-feed while taking Metaxalone .When used for long periods of time or at high doses,
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Forty patients were treated with either Metaxalone suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Metaxalone 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Metaxalone may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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Metaxalone is used to relieve moderate to moderately severe pain.
Metaxalone was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.

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Use Metaxalone with caution in the ELDERLY; they may be more sensitive to its effects.Metaxalone should not be used in CHILDREN younger than 16 years old;
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